Setting Up a Telehealth Practice as an NP: What You Need, What to Avoid, and How to Get Patients

Clinic & Practice · 11 min read · April 28, 2025

The COVID-19 pandemic accelerated telehealth adoption by approximately a decade. What was a niche service delivery model in 2019 became mainstream infrastructure by 2021. And while utilization has moderated from its pandemic peak, telehealth has permanently changed patient expectations and practice models in ways that create genuine opportunity for independent nurse practitioners.

A telehealth-first practice has structural advantages that brick-and-mortar practices do not: lower overhead (no lease, no front desk staff, no waiting room), geographic flexibility (you can practice from anywhere in states where you are licensed), and scalability (adding patients does not require adding physical space).

What Telehealth Can and Cannot Do

Before building a telehealth practice, be honest about its clinical limitations. Telehealth is excellent for:

  • Chronic disease management (hypertension, diabetes, hypothyroidism, depression, anxiety)
  • Medication management and refills
  • Mental health and behavioral health
  • Dermatology (photo-based assessment)
  • Urgent care for low-acuity presentations (UTI, URI, conjunctivitis)
  • Health coaching and wellness visits
  • Hormone replacement therapy management
  • Weight management

Telehealth is not appropriate for:

  • Any presentation requiring physical examination (acute abdominal pain, chest pain, suspected fracture)
  • Pediatric well-child visits requiring growth measurement and developmental assessment
  • Procedures of any kind
  • Patients in acute distress

Your practice scope should be defined by what telehealth can do well, not by what you wish it could do.

Licensing and Interstate Compact

You can only practice telehealth in states where you hold a valid NP license. The Nurse Licensure Compact (NLC) allows RNs to practice across member states on a single license, but the NP compact (APRN Compact) is not yet widely adopted — as of 2025, only a handful of states have enacted it.

If you want to practice telehealth across multiple states, you will need individual state licenses for each state. This is time-consuming and expensive (licensing fees range from $100–$500 per state), but it significantly expands your potential patient population. Many telehealth NPs hold licenses in 5–10 states.

Technology Requirements

A telehealth practice requires:

  • HIPAA-compliant video platform: Doxy.me (free tier available), Zoom for Healthcare, or Teladoc's white-label platform
  • EHR: Athenahealth, Practice Fusion, or a telehealth-native EHR like Osmind (for mental health) or Cerbo (for functional medicine)
  • E-prescribing: Most EHRs include this; you need DEA registration for controlled substances
  • Payment processing: Stripe, Square, or your EHR's integrated billing
  • Scheduling: Calendly, Acuity, or your EHR's scheduling module
  • Reliable internet: A minimum of 25 Mbps upload speed; a wired ethernet connection is strongly preferred over WiFi

Getting Your First Patients

The hardest part...